Blar i forfatter "Engedal, Knut"

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    • Cohort profile: the Norwegian Registry of Persons Assessed for Cognitive Symptoms (NorCog) - a national research and quality registry with a biomaterial collection 

      Medbøen, Ingrid Tøndel; Persson, Karin Ester Torun; Nåvik, Marit; Totland, Torunn Holm; Bergh, Sverre; Treviño, Cathrine Selnes; Ulstein, Ingun; Engedal, Knut; Knapskog, Anne Brita; Brækhus, Anne; Øksengård, Anne Rita; Horndalsveen, Peter Otto; Saltvedt, Ingvild; Lyngroth, Anne Liv; Ranhoff, Anette Hylen; Skrettingland, Dagny B; Naik, Mala; Soares, Jelena Zugic; Johnsen, Bente; Selbæk, Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-08)
      Purpose - The Norwegian Registry of Persons Assessed for Cognitive Symptoms (NorCog) was established to harmonise and improve the quality of diagnostic practice across clinics assessing persons with cognitive symptoms in Norwegian specialist healthcare units and to establish a large research cohort with extensive clinical data.<p> <p>Participants - The registry recruits patients who are referred ...

    • The effect of blood pressure on cognitive performance. An 8-year follow-up of the Tromsø Study, comprising people aged 45–74 Years 

      Hestad, Knut; Engedal, Knut; Schirmer, Henrik; Strand, Bjørn Heine (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-21)
      <i>Background</i>: The relationship between blood pressure (BP) and cognition is complex were age appears to be an intervening variable. High and low BP have been associated with cognitive deficits as part of the aging process, but more studies are needed, especially in more recent birth cohorts.<p><p> <i>Methods</i>: The study sample comprised 4,465 participants, with BP measured at baseline in ...

    • Exploration of 27 plasma immune markers: A cross-sectional comparison of 64 old psychiatric inpatients having unipolar major depression and 18 non-depressed old persons 

      Gaarden, Torfinn Lødøen; Engedal, Knut; Saltyte Benth, Jurate; Larsen, Marianne; Lorentzen, Bernhard; Mollnes, Tom Eirik; Bjølseth, Tor Magne; Castellheim, Albert (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-25)
      <p><i>Background</i>: The prevalence of major depression (MD) according to population studies is the same for old (65 years and older) and younger adults. In contrast, an elevated proportion of old MD patients are hospitalized compared to younger adults with MD, indicating a need to expand the characteristics of old inpatients with MD. To illustrate this point, the association between inflammation ...

    • Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci 

      Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fredrik; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Andreassen, Ole Andreas (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-27)
      A large fraction of genetic risk factors for Alzheimer’s Disease (AD) is still not identified, limiting the understanding of AD pathology and study of therapeutic targets. We conducted a genome-wide association study (GWAS) of AD cases and controls of European descent from the multi-center DemGene network across Norway and two independent European cohorts. In a two-stage process, we first performed ...

    • Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis 

      Hestad, Knut A.; Engedal, Knut; Whist, Jon Elling; Aukrust, Pål; Farup, Per Grønaas; Mollnes, Tom Eirik; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-13)
      INTRODUCTION: Several reports indicate that inflammation may play a role in depression and demonstrate enhanced systemic levels of inflammatory mediators. We hypothesized that 44 patients with a diagnosis of depression would present with a specific and different serum and cerebrospinal fluid (CSF) cytokine profile compared to 21 patients with diffuse neurological symptoms, of whom 15 had fatigue as ...